Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery
S De Koker, J Cui, N Vanparijs, L Albertazzi, J Grooten, F Caruso, BG De Geest
Angewandte Chemie International Edition | Wiley-VCH Verlag | Published : 2016
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The induction of antigen-specific adaptive immunity exclusively occurs in lymphoid organs. As a consequence, the efficacy by which vaccines reach these tissues strongly affects the efficacy of the vaccine. Here, we report the design of polymer hydrogel nanoparticles that efficiently target multiple immune cell subsets in the draining lymph nodes. Nanoparticles are fabricated by infiltrating mesoporous silica particles (ca. 200 nm) with poly(methacrylic acid) followed by disulfide-based crosslinking and template removal. PEGylation of these nanoparticles does not affect their cellular association in vitro, but dramatically improves their lymp..View full abstract
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Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council under Australian Laureate Fellowship
This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030). Dr. Ken Rock (University of Massachusetts Medical School) is gratefully acknowledged for providing the DC2.4 cell line. S.D.K. and B.G.D.G. acknowledge the FWO Flanders for funding. N.V. acknowledges BOF-UGent for a PhD scholarship.