Journal article
Childhood metabolic syndrome, inflammation and carotid intima-media thickness. the Aboriginal Birth Cohort Study
M Juonala, GR Singh, B Davison, K Van Schilfgaarde, MR Skilton, MA Sabin, M Cheung, S Sayers, DP Burgner
International Journal of Cardiology | Published : 2016
Abstract
Background/objectives We evaluated whether atherosclerotic changes associated with MetS in Australian Aboriginals are reversible in childhood. In addition, we investigated whether heightened inflammation is mediating the adverse effects of MetS. Methods The study cohort comprised of 351 children from the Aboriginal Birth Cohort Study (a longitudinal study based in the Northern Territory of Australia) aged 9-13 years at baseline examination who were followed up 6 years later. MetS was defined by at least three of the following parameters within the extreme sex- and age-specific quartile: highest quartile for waist circumference, blood pressure, triglycerides, and glucose, and lowest quartile ..
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Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia, the Channel 7 Children's Research Foundation of South Australia, the National Heart Foundation of Australia and a Northern Territory Government Research and Innovation Grant. MJ has been granted by Paulo Foundation, Paavo Nurmi Foundation, Sigrid Juselius Foundation, Maud Kuistila Foundation, research funds from the Turku University Hospital, the Finnish Foundation of Cardiovascular Research and the Finnish Medical Foundation. MRS holds a National Heart Foundation of Australia Future Leader Fellowship (100419). DPB holds a National Health and Medical Research Council Senior Research Fellowship (APP1064629) and an honorary National Heart Foundation Future Leader Fellowship (100369). Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group at Murdoch Childrens Research Institute is supported by Big W and RCH 1000, RCH Foundation. The sponsors had no role in preparing the manuscript.