Journal article
Subjective memory complaints in APOE ε4 carriers are associated with high Amyloid-β Burden
MD Zwan, VL Villemagne, V Doré, R Buckley, P Bourgeat, R Veljanoski, O Salvado, R Williams, L Margison, A Rembach, SL Macaulay, R Martins, D Ames, WM Van Der Flier, KA Ellis, P Scheltens, CL Masters, CC Rowe
Journal of Alzheimer S Disease | Published : 2015
DOI: 10.3233/JAD-150446
Abstract
Background: APOEε4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning. Objective: To assess whether APOEε4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly. Methods: 307 cognitively normal participants (72.7±6.8 years, 53% female, 55% SMC) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and APOE genotyping. Logistic regression analyses were performed to determine the association of APOEε4 genotype, age, SMC, and..
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Awarded by National Health Medical Research Council (NHMRC) of Australia
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
We thank the AIBL Study Group (http://www.aibl.csiro.au) and A/Prof. Michael Woodward, Dr. John Merory, Dr. Peter Drysdale, Dr. Rachel Mulligan, Dr. Uwe Ackermann, Dr. Gordon Chan, and Dr. Kenneth Young, for their assistance with this study. We thank Alzheimer Nederland and Internationale Stichting Alzheimer Onderzoek (ISAO) for providing fellowships to M.Z. to conduct the research at Austin Health, Heidelberg, Victoria, Australia. The present study was supported by the Commonwealth Scientific Industrial Research Organization (CSIRO) P-Health Flagship Collaboration Fund through the Australian Imaging, Biomarkers and Lifestyle Flagship study of Ageing (Australian Imaging, Biomarkers and Lifestyle [AIBL]), the Science and Industry Endowment Fund (SIEF), GE Healthcare, the Austin Hospital Medical Research Foundation, Project Grant 1071430 from the National Health Medical Research Council (NHMRC) of Australia for collection and management of the data. CCR had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.