Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria
Wilson L Mandala, Chisomo L Msefula, Esther N Gondwe, James J Gilchrist, Stephen M Graham, Paul Pensulo, Grace Mwimaniwa, Meraby Banda, Terrie E Taylor, Elizabeth E Molyneux, Mark T Drayson, Steven A Ward, Malcolm E Molyneux, Calman A MacLennan
CLINICAL AND VACCINE IMMUNOLOGY | AMER SOC MICROBIOLOGY | Published : 2016
Lymphocytes are implicated in immunity and pathogenesis of severe malaria. Since lymphocyte subsets vary with age, assessment of their contribution to different etiologies can be difficult. We immunophenotyped peripheral blood from Malawian children presenting with cerebral malaria, severe malarial anemia, and uncomplicated malaria (n = 113) and healthy aparasitemic children (n = 42) in Blantyre, Malawi, and investigated lymphocyte subset counts, activation, and memory status. Children with cerebral malaria were older than those with severe malarial anemia. We found panlymphopenia in children presenting with cerebral malaria (median lymphocyte count, 2,100/μl) and uncomplicated malaria (3,70..View full abstract
Awarded by Wellcome Trust
Gates Malaria Partnership PhD Studentship provided funding to Wilson L Mandala. Wellcome Trust Research Fellowship provided funding to Calman A MacLennan under grant number 067902/Z/02/Z. GlaxoSmithKline Clinical Research Fellowship provided funding to Calman A MacLennan. Wellcome Trust Programme Grant provided funding to Malcolm Molyneux under grant number 074124/Z/04/Z.