Journal article
Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea
M Laman, I Hwaiwhanje, C Bona, J Warrel, S Aipit, D Smith, J Noronha, P Siba, I Mueller, I Betuela, TME Davis, L Manning
BMC Infectious Diseases | BIOMED CENTRAL LTD | Published : 2014
Abstract
Background: Viral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS infection. Methods: We performed a prospective study of Papua New Guinean children hospitalized with signs and symptoms of CNS infection. CSF samples from 300 children without proven bacterial/fungal meningitis were analyzed for human herpes viruses (HHV), picornaviruses, influenza, adenoviruses, flaviviruses and bacteria. Results: Fifty-five children (18%) had viral (42), bac..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was partly funded by the WHO-Western Pacific Region under the TDR Small Grants Programme for Operational Research on Communicable Diseases. Additional infrastructure for the study was funded by a National Health and Medical Research Council (NHMRC) grant (#513782). The authors also acknowledge support from the MalariaGen Genomic Epidemiology Network. LM was supported by a Basser scholarship from the Royal Australasian College of Physicians and an NHMRC scholarship, ML was supported by a Fogarty Foundation scholarship, and TMED by an NHMRC Practitioner Fellowship. None of the funding bodies were involved in study design, in the collection, analysis, and interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication.