Journal article

Beta-glucan-depleted, glycopeptide-rich extracts from Brewer's and Baker's yeast (Saccharomyces cerevisiae) lower interferon-gamma production by stimulated human blood cells in vitro

Roderick Williams, Daniel A Dias, Nirupama Jayasinghe, Ute Roessner, Louise E Bennett



Regulation of the human immune system requires controlled pro- and anti-inflammatory responses for host defence against infection and disease states. Yeasts (Saccharomyces cerevisiae), as used in brewing and baking, are mostly known for ability to stimulate the human immune-system predominantly reflecting the pro-inflammatory cell wall β-glucans. However, in this study, using food-compatible processing methods, glycopeptide-enriched and β-glucan-depleted products were each prepared from Brewer's and Baker's yeasts, which suppressed production of interferon-γ (IFN-γ) in human whole blood cell assay, signifying that anti-inflammatory factors are also present in yeast. Anti-inflammatory bioacti..

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Funding Acknowledgements

The preparation of yeast products by Katherine Robinson, Jennifer Favaro and Sunanda Sudharmarajan, cell culture experiments by Santina Forsyth and carbohydrate analysis by Bruce May and Tony Bird, are gratefully acknowledged. We also acknowledge funding support from CSIRO Food and Nutrition. Metabolite profiling was conducted by the University of Melbourne node of Metabolomics Australia, Parkville, Australia.