Journal article

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

Edmond M Linossi, Sandra E Nicholson

IMMUNOLOGICAL REVIEWS | WILEY | Published : 2015

Abstract

The suppressor of cytokine signaling (SOCS) family of proteins are key negative regulators of cytokine and growth factor signaling. They act at the receptor complex to modulate the intracellular signaling cascade, preventing excessive signaling and restoring homeostasis. This regulation is critical to the normal cessation of signaling, highlighted by the complex inflammatory phenotypes exhibited by mice deficient in SOCS1 or SOCS3. These two SOCS proteins remain the best characterized of the eight family members (CIS, SOCS1-7), and in particular, we now possess a sound understanding of the mechanism of action for SOCS3. Here, we review the mechanistic role of the SOCS proteins and identify e..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC IRIISS grant


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC; Program grant 1016647), an NHMRC IRIISS grant 361646 and Victorian State Government Operational Infrastructure Scheme Grant. E. M. L. is the recipient of an Australian Postgraduate Award. The authors would like to thank Prof Nick Nicola and Dr Jeff Babon for ongoing intellectual discussions. None of the authors has a financial interest related to this work.