Journal article
Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses
CA Russell, TC Jones, IG Barr, NJ Cox, RJ Garten, V Gregory, ID Gust, AW Hampson, AJ Hay, AC Hurt, JC de Jong, A Kelso, AI Klimov, T Kageyama, N Komadina, AS Lapedes, YP Lin, A Mosterin, M Obuchi, T Odagiri Show all
Vaccine | ELSEVIER SCI LTD | Published : 2008
Abstract
Annual influenza epidemics in humans affect 5-15% of the population, causing an estimated half million deaths worldwide per year [Stohr K. Influenza-WHO cares. Lancet Infectious Diseases 2002;2(9):517]. The virus can infect this proportion of people year after year because the virus has an extensive capacity to evolve and thus evade the immune response. For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza vaccine has had to be updated almost 30 times to track the evolution of the viruses and remain effective. The World Health Organization Global Influenza Surveillance Network (WHO GISN) tracks and analyzes the evolution ..
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Awarded by National Institutes of Health
Funding Acknowledgements
We are thankful for the enormous contributions of individuals throughout the WHO Global Influenza Surveillance Network, particularly those in National Influenza Centers. This work was supported by an NIH Director's Pioneer Award to DJS, part of the NIH roadmap for medical research, through grant number DP1-OD000490-01. RAMF is supported by NIAID-NIH contract HHSN266200700010C, and the De Nederlandse Organisatie voor Wetenschappelijk Onderzoek Netherlands Influenza Vaccine Research Centre. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. The WHO Collaborating Centre for Influenza, NIMR, UK is funded by The Medical Research Council (UK). The conclusions presented in this paper are those of the authors and do not necessarily reflect those of the funding agencies.