Journal article

Interaction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of rat

Willian Seiji Korim, Marcos L Ferreira-Neto, Gustavo R Pedrino, Paul M Pilowsky, Sergio L Cravo

PURINERGIC SIGNALLING | SPRINGER | Published : 2012

Abstract

In the nucleus tractus solitarii (NTS) of rats, blockade of extracellular ATP breakdown to adenosine reduces arterial blood pressure (AP) increases that follow stimulation of the hypothalamic defense area (HDA). The effects of ATP on NTS P2 receptors, during stimulation of the HDA, are still unclear. The aim of this study was to determine whether activation of P2 receptors in the NTS mediates cardiovascular responses to HDA stimulation. Further investigation was taken to establish if changes in hindlimb vascular conductance (HVC) elicited by electrical stimulation of the HDA, or activation of P2 receptors in the NTS, are relayed in the rostral ventrolateral medulla (RVLM); and if those respo..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)


Funding Acknowledgements

Willian Seiji Korim is supported by a Macquarie Research Excellence Scholarship and a Coordenadoria de Aperfeicoamento em Pesquisa (CAPES-DS) Scholarship. Work in the Author's laboratories is supported by the National Health and Medical Research Council of Australia (457069, 457080 and 604002), Australian Research Council (DP110102110), the Garnett Passe and Rodney Williams Memorial Foundation, Macquarie University and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; #477832/2010-5).