Interaction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of rat
Willian Seiji Korim, Marcos L Ferreira-Neto, Gustavo R Pedrino, Paul M Pilowsky, Sergio L Cravo
PURINERGIC SIGNALLING | SPRINGER | Published : 2012
In the nucleus tractus solitarii (NTS) of rats, blockade of extracellular ATP breakdown to adenosine reduces arterial blood pressure (AP) increases that follow stimulation of the hypothalamic defense area (HDA). The effects of ATP on NTS P2 receptors, during stimulation of the HDA, are still unclear. The aim of this study was to determine whether activation of P2 receptors in the NTS mediates cardiovascular responses to HDA stimulation. Further investigation was taken to establish if changes in hindlimb vascular conductance (HVC) elicited by electrical stimulation of the HDA, or activation of P2 receptors in the NTS, are relayed in the rostral ventrolateral medulla (RVLM); and if those respo..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Willian Seiji Korim is supported by a Macquarie Research Excellence Scholarship and a Coordenadoria de Aperfeicoamento em Pesquisa (CAPES-DS) Scholarship. Work in the Author's laboratories is supported by the National Health and Medical Research Council of Australia (457069, 457080 and 604002), Australian Research Council (DP110102110), the Garnett Passe and Rodney Williams Memorial Foundation, Macquarie University and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; #477832/2010-5).