Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

GM Tannahill; AM Curtis; J Adamik; EM Palsson-McDermott; AF McGettrick; G Goel; C Frezza; NJ Bernard; B Kelly; NH Foley; L Zheng; A Gardet; Z Tong; SS Jany; SC Corr; M Haneklaus; BE Caffrey; K Pierce; S Walmsley; FC Beasley; E Cummins; V Nizet; M Whyte; CT Taylor; H Lin; SL Masters; E Gottlieb; VP Kelly; C Clish; PE Auron; RJ Xavier; LAJ O'Neill

Journal article

Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, L Zheng, A Gardet, Z Tong, SS Jany, SC Corr, M Haneklaus, BE Caffrey, K Pierce, S Walmsley, FC Beasley Show all

Nature | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/nature11986

University of Melbourne Researchers

Seth Masters Author Medical Biology (W.E.H.I.)

Grants

Awarded by Medical Research Council

Funding Acknowledgements

We thank the European Research Council, Science Foundation Ireland, the Health Research Board, European Union FP7 programme 'TIMER', Wellcome Trust, National Institutes of Health, Helmsley Trust, Nestle Research Centre, VESKI, The Duquesne University Hunkele Dreaded Disease Award, The Interleukin Foundation and the National Health and Medical Research Council for funding. We also thank R. Thompson for assistance with Hif1a<SUP>-/-</SUP> mice and M. Murphy for discussions.