Journal article

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C Coll, Avril AB Robertson, Jae Jin Chae, Sarah C Higgins, Raul Munoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz, Daniel E Croker, Mark S Butler, Moritz Haneklaus, Caroline E Sutton, Gabriel Nunez, Eicke Latz, Daniel L Kastner, Kingston HG Mills, Seth L Masters, Kate Schroder Show all

Nature Medicine | NATURE PUBLISHING GROUP | Published : 2015

University of Melbourne Researchers


Awarded by Science Foundation Ireland

Awarded by Australian Research Council

Awarded by US National Institutes of Health

Awarded by German Research Foundation

Awarded by National Health and Medical Research Council of Australia

Awarded by ERC Advanced Grant

Funding Acknowledgements

We thank A. Kitanovic (German Center for Neurodegenerative Diseases) for image analysis (Fig. 3c), S. Corr (Trinity College Dublin) for providing S. typhimurium UK-1 strain and H.M. Hoffman (University of California, San Diego) for providing Nlrp3 (A350VneoR) mice. This work was supported by the following funding bodies, grants and fellowships. L.A.J.O'N. and R.C.C.: Science Foundation Ireland (G20598). D.L.K. and J.J.C.: Intramural Research Program of the National Human Genome Research Institute, US National Institutes of Health. S.C.H., C.E.S. and K.H.G.M.: Science Foundation Ireland (11/PI/1036) and (07/SRC/B1144). I.V.: Australian Research Council (FT130101215). G.N.: US National Institutes of Health (DK091191) and (DK095782). E.L.: German Research Foundation (SFB645, SFB670, SFB704, TRR57), European Research Council (ERC, InflammAct) and Excellence Cluster ImmunoSensation. S.L.M.: VESKI innovation fellowship and National Health and Medical Research Council of Australia (1032065) and (1057815). K.S.: Queensland Smart Futures Fund and Australian Research Council (FT130100361). L.A.J.O'N.: ERC Advanced Grant (E12435).