Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood

TB Nguyen; JM Gunn; M Potiriadis; IP Everall; CA Bousman

Journal article

Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood

TB Nguyen, JM Gunn, M Potiriadis, IP Everall, CA Bousman

Bjpsych Open | ROYAL COLL PSYCHIATRISTS | Published : 2015

DOI: 10.1192/bjpo.bp.115.000380

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Abstract

Background Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and major depressive disorder. Aims To examine whether the 5HTTLPR polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood. Method At 5-year follow-up, DNA from 333 adult primary care attendees was obtained and genotyped for the 5HTTLPR polymorphism. Linear mixed models were used to test for a genotype × childhood abuse interaction effect on 5-year depressive symptom severity trajectories. Results After covariate adjustment, homozyg..

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University of Melbourne Researchers

Jane Gunn Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The diamond study is funded by the National Health and Medical Research Council (IDs 299869, 454463, 566511 and 1002908) and the Victorian Centre for Excellence in Depression and Related Disorders, an initiative between beyondblue and the Victorian Government. The collection of DNA and genotyping was funded by the LEW Carty Chartable Fund (ID 7284). No funding body had a role in the study design; the collection, analysis and interpretation of data; or the writing of the manuscript for publication. We acknowledge the 30 dedicated general practitioners their patients and practice staff for making this research possible.