The impact of premorbid and current intellect in schizophrenia: Cognitive, symptom, and functional outcomes

R Wells; V Swaminathan; S Sundram; D Weinberg; J Bruggemann; I Jacomb; V Cropley; R Lenroot; AM Pereira; A Zalesky; C Bousman; C Pantelis; CS Weickert; TW Weickert

Journal article

The impact of premorbid and current intellect in schizophrenia: Cognitive, symptom, and functional outcomes

R Wells, V Swaminathan, S Sundram, D Weinberg, J Bruggemann, I Jacomb, V Cropley, R Lenroot, AM Pereira, A Zalesky, C Bousman, C Pantelis, CS Weickert, TW Weickert

Npj Schizophrenia | SPRINGERNATURE | Published : 2015

DOI: 10.1038/npjschz.2015.43

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Abstract

BACKGROUND: Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelligence quotient (IQ) estimates. In a relatively large, community cohort, we aimed to independently replicate and extend cognitive subtyping work by determining the extent of symptom severity and functional deficits in each group. METHODS: A total of 635 healthy controls and 534 patients with a diagnosis of schizophrenia or schizoaffective disorder were recruited through the Australian Schizophrenia Research Bank. Patients were classified into cognitive subgroups on the basis of the Wechsler Test of Adult Reading (a premorbid IQ estimate) and current overall cogniti..

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University of Melbourne Researchers

Vanessa Cropley Author

Andrew Zalesky Author

Christos Pantelis Author

Related Projects (1)

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank the ASRB Chief Investigators: Carr V, Schall U, Scott R, Jablensky A, Mowry B, Michie P, Pantelis C, Catts S, Henskens F, and ASRB Manager: Loughland C for the compilation of this resource. This work was supported by the University of New South Wales School of Psychiatry, Neuroscience Research Australia, the Schizophrenia Research Institute utilizing infrastructure funding from NSW Ministry of Health and the Macquarie Group Foundation, the Florey Institute of Neuroscience and Mental Health through the Victorian State Government Operational Infrastructure Support program and One-in-Five Association Incorporated, and the Australian Schizophrenia Research Bank which is supported by the Australian National Health and Medical Research Council (NHMRC), the Pratt Foundation, Ramsay Health Care, and the Viertel Charitable Foundation. An Australian NHMRC Senior Research Fellowship (#1021970) supported CSW. An Australian NHMRC Senior Principal Research Fellowship (ID: 628386) supported CP. An Australian NHMRC Early Career Research Fellowship (ID: 62880) supported VC.