Journal article

STRUCTURE-ACTIVITY-RELATIONSHIPS FOR PLATELET-ACTIVATING-FACTOR (PAF) AND ANALOGS REVEAL DIFFERENCES BETWEEN PAF RECEPTORS ON PLATELETS AND MACROPHAGES

AG STEWART, G GRIGORIADIS

JOURNAL OF LIPID MEDIATORS | ELSEVIER SCIENCE BV | Published : 1991

Abstract

Analogues of PAF were examined for their potency in stimulating either platelet aggregation or macrophage superoxide anion generation. Modification of either the alkyl side-chain or the acetyl side-chain increased the relative potency of PAF analogues in macrophages, but all these compounds were more active in platelets. However, an analogue of PAF with an increased inter-ionic distance in the polar head group, hexanolamine PAF, showed a greater potency in macrophages than platelets. The latter compound also appeared to act as a partial agonist in both rabbit platelets and guinea-pig macrophages, but not in guinea-pig platelets. Differences in the rank order of potency of the PAF analogues i..

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