OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis
Heidi S Schultz, Li Guo, Pernille Keller, Andrew J Fleetwood, Mingyi Sun, Wei Guo, Chunyan Ma, John A Hamilton, Olle Bjorkdahl, Martin W Berchtold, Svetlana Panina
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2016
Osteoclast-associated receptor (OSCAR) is an activating receptor expressed by human myeloid cells. Collagen type I (ColI) and collagen type II (ColII) serve as ligands for OSCAR. OSCAR-collagen interaction stimulates RANK-dependent osteoclastogenesis. We have recently reported that OSCAR promotes functional maturation of monocyte-derived dendritic cells. OSCAR is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential. In the current study, we have addressed a functional role for an OSCAR-collagen interaction on monocytes. We show that OSCAR-ColII signaling promoted the survival of monocytes. Mo..View full abstract
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H.S.S. was supported by a PhD fellowship from the Danish Agency for Science, Technology, Innovation and Research. M.W.B. was supported by the Danish Research Council for Independent Research. Authors contribution: H.S.S. and A. F. performed the experiments with cells from healthy donors; L.G., M.D., W.G., and C.M. performed experiments with clinical samples; P.K. performed microarray studies; S.P., J.H., O.B., and M.W.B. contributed to the study design and the manuscript preparation. H.S.S. and S.P. prepared the manuscript. All authors have approved the final version of the manuscript. The authors thank Majken A. Johannesen, Lise W.F. Jensen, Jette Platou, and Helene Bregnbak for excellent technical support.