Y1 signalling has a critical role in allergic airway inflammation
Laurence Macia, Priya T Rao, Julie Wheway, Frederic Sierro, Fabienne Mackay, Herbert Herzog
Immunology and Cell Biology | NATURE PUBLISHING GROUP | Published : 2011
Asthma affects 300 million people worldwide, yet the mechanism behind this pathology has only been partially elucidated. The documented connection between psychological stress and airway inflammation strongly suggests the involvement of the nervous system and its secreted mediators, including neuropeptides, on allergic respiratory disease. In this study, we show that neuropeptide Y (NPY), a prominent neurotransmitter, which release is strongly upregulated during stress, exacerbates allergic airway inflammation (AAI) in mice, via its Y1 receptor. Our data indicate that the development of AAI was associated with elevated NPY expression in the lung and that lack of NPY-mediated signalling in NP..View full abstract
We thank the staff of the Garvan Institute Biological Testing Facility for facilitation of these experiments. This research was supported by a grant from the National Health and Medical Research Council (NHMRC) of Australia and NHMRC Fellowships to HH and FM.