Non-coding RNAs in mammalian sexual development

Abstract

The present decade is witnessing a paradigm shift in our understanding of gene regulationRNA, once relegated to an intermediary between DNA and protein, has emerged as a key contributor in the coordination of complex developmental pathwaysFor sexually reproducing organisms, propagation of the species is accomplished via an elaborate sexual phenotypeIn mammals this consists of a highly complex cell lineage that has the capacity for intricate self-differentiation whilst maintaining the potential to generate all cell types upon fertilizationIn addition, mammals possess a diverse range of somatic reproductive tissues and organs that often undergo dynamic morphological changes in response to a va..