Journal article
A New Model of Development of the Mammalian Ovary and Follicles
K Hummitzsch, HF Irving-Rodgers, N Hatzirodos, W Bonner, L Sabatier, DP Reinhardt, Y Sado, Y Ninomiya, D Wilhelm, RJ Rodgers
Plos One | Published : 2013
Abstract
Ovarian follicular granulosa cells surround and nurture oocytes, and produce sex steroid hormones. It is believed that during development the ovarian surface epithelial cells penetrate into the ovary and develop into granulosa cells when associating with oogonia to form follicles. Using bovine fetal ovaries (n = 80) we identified a novel cell type, termed GREL for Gonadal Ridge Epithelial-Like. Using 26 markers for GREL and other cells and extracellular matrix we conducted immunohistochemistry and electron microscopy and chronologically tracked all somatic cell types during development. Before 70 days of gestation the gonadal ridge/ovarian primordium is formed by proliferation of GREL cells ..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council of Australia, the University of Adelaide and the Clive and Vera Ramaciotti Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.