Journal article

Tissue-resident memory T cells: local specialists in immune defence

Scott N Mueller, Laura K Mackay

NATURE REVIEWS IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2016

Abstract

T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the different..

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