The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
Myles R Minter, Juliet M Taylor, Peter J Crack
JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 2016
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia. Deposition of amyloid-β (Aβ) remains a hallmark feature of the disease, yet the precise mechanism(s) by which this peptide induces neurotoxicity remain unknown. Neuroinflammation has long been implicated in AD pathology, yet its contribution to disease progression is still not understood. Recent evidence suggests that various Aβ complexes interact with microglial and astrocytic expressed pattern recognition receptors that initiate innate immunity. This process involves secretion of pro-inflammatory cytokines, chemokines and generation of reactive oxygen species that, in excess, drive a ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (APP1044714) to PJC and JMT. PJC is an Australian Research Council (ARC) Future Fellow. MRM holds an Alzheimer's Australia Dementia Research Fund (AADRF) postgraduate scholarship. The authors declare they have no competing interests.