Journal article
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
M Traylor, CR Zhang, P Adib-Samii, WJ Devan, OE Parsons, S Lanfranconi, S Gregory, L Cloonan, GJ Falcone, F Radmanesh, K Fitzpatrick, A Kanakis, TR Barrick, B Moynihan, CM Lewis, GB Boncoraglio, R Lemmens, V Thijs, C Sudlow, J Wardlaw Show all
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
Abstract
Objective: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. Methods: We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-..
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Awarded by National Institutes of Health
Funding Acknowledgements
Funding for collection, genotyping, and analysis of stroke samples was provided by Wellcome Trust Case Control Consortium-2, a functional genomics grant from the Wellcome Trust (DNA-Lacunar), the Stroke Association (DNA-Lacunar), the Intramural Research Program of National Institute of Ageing (Massachusetts General Hospital [MGH] and Ischemic Stroke Genetics Study [ISGS]), National Institute of Neurological Disorders and Stroke (Siblings With Ischemic Stroke Study, ISGS, and MGH), the American Heart Association/Bugher Foundation Centers for Stroke Prevention Research (MGH), Deane Institute for Integrative Study of Atrial Fibrillation and Stroke (MGH), National Health and Medical Research Council (Australian Stroke Genetics Collaborative), and Italian Ministry of Health (Milan). Additional support for sample collection came from the Medical Research Council, National Institute of Health Research Biomedical Research Centre and Acute Vascular Imaging Centre (Oxford), Wellcome Trust and Binks Trust (Edinburgh), and Vascular Dementia Research Foundation (Munich). M.T. is supported by a project grant from the Stroke Association (TSA 2013/01). H.S.M. is supported by an NIHR Senior Investigator award. H.S.M. and S.B. are supported by the NIHR Cambridge University Hospitals Comprehensive Biomedical Research Centre. V.T. and R.L. are supported by grants from FWO Flanders. P.R. holds NIHR and Wellcome Trust Senior Investigator Awards. P.A.S. is supported by an MRC Fellowship. C.M.L.'s research is supported by the National Institute for Health Research Biomedical Research Centre (BRC) based at Guy's and St Thomas' NHS Foundation Trust and King's College London, and the BRC for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London.