HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy
Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2016
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC IRIISS grant
We thank Dr Vishva Dixit for kindly providing Ripk3<SUP>-/-</SUP> mice, Dr Toru Okamoto for developing the inducible expression vector, Drs Marie-Liesse Asselin-Labat and Chris Burns for providing AT13387, and Mr Sam Young for assistance in generating expression constructs. This work was supported by National Health and Medical Research Council of Australia (NHMRC) grants (1067289, 1016647, 1057888, 1057905, 1046010 and 1016701) and fellowships to MFvD (516795), JMH (541951), DCSH (1043149) and JS (541901, 1058190); a Victorian International Research Scholarship to MCT; with additional support from the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support Scheme and an NHMRC IRIISS grant (9000220). This research was facilitated by Compounds Australia; a joint initiative of Griffith University and the Queensland Government through the Smart State Innovation Fund administered by the Department of Tourism, Regional Development and Industry.