Journal article

Depression as a risk factor for fracture in women: A 10 year longitudinal study

Lana J Williams, Julie A Pasco, Henry Jackson, Litza Kiropoulos, Amanda L Stuart, Felice N Jacka, Michael Berk

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2016

Abstract

BACKGROUND: Previous research has demonstrated deficits in bone mineral density (BMD) among individuals with depression. While reduced BMD is a known risk for fracture, a direct link between depression and fracture risk is yet to be confirmed. METHODS: A population-based sample of women participating in the Geelong Osteoporosis Study was studied using both nested case-control and retrospective cohort study designs. A lifetime history of depression was identified using a semi-structured clinical interview (SCID-I/NP). Incident fractures were identified from radiological reports and BMD was measured at the femoral neck using dual energy absorptiometry. Anthropometry was measured and informatio..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

The study was funded by the National Health and Medical Research Council (NHMRC, projects 1009367, 509103 and 628582), Australia. LJW is supported by a NHMRC Career Development Fellowship (1064272). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). The funding providers played no role in the design or conduct of the study; collection, management, analysis, and interpretation of the data; or in preparation, review, or approval of the manuscript.