The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes
Ayal B Gussow, Slave Petrovski, Quanli Wang, Andrew S Allen, David B Goldstein
Genome Biology | BIOMED CENTRAL LTD | Published : 2016
Awarded by National Institute of Neurological Disorders and Stroke of the National Institutes of Health
Awarded by NIH Epi4K Sequencing, Bioinformatics and Biostatistics
ABG is supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number F31NS092362. SP is a National Health and Medical Research Council of Australia (NHMRC) (CJ Martin) Early Career Fellow. This work was supported in part by the NIH Epi4K Sequencing, Bioinformatics and Biostatistics Core grant number U01NS077303. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; in the decision to submit the manuscript for publication.