Journal article
Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension)
M Beghetti, I Schulze-Neick, RMF Berger, DD Ivy, D Bonnet, RG Weintraub, T Saji, D Yung, GB Mallory, R Geiger, JT Berger, RJ Barst, T Humpl, S Mattos, ZC Jing, ZY Han, L Sondergaard, T Jensen, M Levy, S Mebus Show all
International Journal of Cardiology | Published : 2016
Abstract
Background The TOPP Registry has been designed to provide epidemiologic, diagnostic, clinical, and outcome data on children with pulmonary hypertension (PH) confirmed by heart catheterisation (HC). This study aims to identify important characteristics of the haemodynamic profile at diagnosis and HC complications of paediatric patients presenting with PH. Methods and results HC data sets underwent a blinded review for confirmation of PH (defined as mean pulmonary arterial pressure ≥ 25 mm Hg, pulmonary capillary wedge pressure ≤ 12 mm Hg and pulmonary vascular resistance index [PVRI] of > 3 WU × m2). Of 568 patients enrolled, 472 who fulfilled the inclusion criteria and had sufficient data fr..
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Funding Acknowledgements
The TOPP Registry is supported by a funding from Actelion Pharmaceuticals Ltd. Actelion does not participate in the management of the Registry, nor does it have access to the database, the individual sites and patient data. All Registry-related decisions lie solely with the Executive Board of the Association for Pediatric Pulmonary Hypertension.