Journal article

Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle

Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, Dietmar Plenz

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2015

Abstract

Pathological changes in excitability of cortical tissue commonly underlie the initiation and spread of seizure activity in patients suffering from epilepsy. Accordingly, monitoring excitability and controlling its degree using antiepileptic drugs (AEDs) is of prime importance for clinical care and treatment. To date, adequate measures of excitability and action of AEDs have been difficult to identify. Recent insights into ongoing cortical activity have identified global levels of phase synchronization as measures that characterize normal levels of excitability and quantify any deviation therefrom. Here, we explore the usefulness of these intrinsic measures to quantify cortical excitability i..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Mental Health


Awarded by Cluster of Excellence BrainLinks-BrainTools


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This study was supported by the Intramural Research Program of the National Institute of Mental Health (ZIAMH002797). This study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health. A.S.-B. would like to acknowledge support by the Cluster of Excellence BrainLinks-BrainTools (EXC-1086).