Journal article
Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial
JA Lowthian, CJ Britt, G Rance, FR Lin, RL Woods, R Wolfe, MR Nelson, HA Dillon, S Ward, CM Reid, JE Lockery, TT Nguyen, JJ McNeil, E Storey
Contemporary Clinical Trials | Published : 2016
Abstract
Background: Age-related hearing loss (ARHL) is a leading cause of disability in the elderly. Low-grade inflammation and microvessel pathology may be responsible for initiating or exacerbating some of the hearing loss associated with aging. A growing body of evidence demonstrates an association of hearing loss with cognitive decline. A shared etiological pathway may include a role of inflammation, alongside vascular determinants. The ASPREE-HEARING study aims to determine whether low-dose aspirin decreases the progression of ARHL, and if so, whether this decrease in progression is also associated with retinal microvascular changes and/or greater preservation of cognitive function. Design and ..
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Awarded by National Health and Medical Research Council Early Career Fellowship
Funding Acknowledgements
ASPREE has received funding from the National Institute on Aging (NIH); the National Health and Medical Research Council of Australia, National Cancer Institute (NIH), the Victorian Cancer Agency (Australia) and Monash University.ASPREE-HEARING has received funding from Monash University and the Deafness Foundation.JL is supported by a National Health and Medical Research Council Early Career Fellowship (1052442).