Journal article
Development of a registration framework to validate MRI with histology for prostate focal therapy
HM Reynolds, S Williams, A Zhang, R Chakravorty, D Rawlinson, CS Ong, M Esteva, C Mitchell, B Parameswaran, M Finnegan, G Liney, A Haworth
Medical Physics | Published : 2015
DOI: 10.1118/1.4935343
Abstract
Purpose: Focal therapy has been proposed as an alternative method to whole-gland treatment for prostate cancer when aiming to reduce treatment side effects. The authors recently validated a radiobiological model which takes into account tumor location and tumor characteristics including tumor cell density, Gleason score, and hypoxia in order to plan optimal dose distributions for focal therapy. The authors propose that this model can be informed using multiparametric MRI (mpMRI) and in this study present a registration framework developed to map prostate mpMRI and histology data, where histology will provide the ground truth data regarding tumor location and biology. The authors aim to apply..
View full abstractGrants
Awarded by Australian Education International, Australian Government
Funding Acknowledgements
Dr. Reynolds is funded by a Movember Young Investigator Grant awarded through Prostate Cancer Foundation of Australia's Research Program. Dr. Williams was partially supported by a Victorian Cancer Agency Fellowship. Work was supported by PdCCRS Grant No. 628592 with funding partners: Prostate Cancer Foundation of Australia and the Radiation Oncology Section of the Australian Government of Health and Aging and Cancer Australia. NICTA is funded by the Australian Government through the Department of Communications and the Australian Research Council through the ICT Centre of Excellence Program. Thanks to Dr. C. Meyers for assistance in initiating this project and Professor Martin Ebert for his contribution during project development and in paper preparation. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.