Journal article

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

Kevin V Chow, Andrew M Lew, Robyn M Sutherland, Yifan Zhan

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2016

Abstract

Monocyte-derived dendritic cells (moDCs) dramatically increase in numbers upon infection and inflammation; accordingly, we found that this also occurs during allogeneic responses. Despite their prominence, how emergent moDCs and resident conventional DCs (cDCs) divide their labor as APCs remain undefined. Hence, we compared both direct and indirect presentation by murine moDCs versus cDCs. We found that, despite having equivalent MHC class II expression and in vitro survival, moDCs were 20-fold less efficient than cDCs at inducing CD4(+) T cell proliferation through both direct and indirect Ag presentation. Despite this, moDCs were more potent at inducing Th1 and Th17 differentiation (e.g., ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council of Australia Independent Research Institutes Infrastructure Support Scheme Grant


Funding Acknowledgements

This work was supported by the Rebecca L. Cooper Foundation, National Health and Medical Research Council of Australia Grants 1037321, 1043414, and 1080321, National Health and Medical Research Council of Australia Independent Research Institutes Infrastructure Support Scheme Grant 361646, and a Victorian State Government Operational Infrastructure Support grant.