Journal article

Increased blood pressure responses in neuropeptide Y transgenic rats

M Michalkiewicz, T Michalkiewicz, DL Kreulen, SJ McDougall

American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2001


Considering the coexistence of neuropeptide Y (NPY) and norepinephrine in perivascular sympathetic nerves and the known vasoconstrictor cooperation of NPY with norepinephrine, we investigated the involvement of NPY in long-term control of cardiovascular functions using NPY transgenic (NPY-tg) rats. These rats were developed by injection of the rat (Sprague-Dawley) pronuclei with a 14.5-kb clone of the rat structural NPY gene. When compared with nontransgenic littermates, NPY concentrations were significantly increased in a number of cardiovascular tissues of NPY-tg hemizygotes. Direct basal mean arterial pressure and heart rate were not changed, but calculated total vascular resistance was s..

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