Journal article
Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "TH2-type" immunity associated with development of food allergy
Y Zhang, F Collier, G Naselli, R Saffery, ML Tang, KJ Allen, AL Ponsonby, LC Harrison, P Vuillermin, S Ranganathan, D Burgner, J Molloy, T Dwyer
Science Translational Medicine | Published : 2016
Abstract
Food allergy is a major health burden in early childhood. Infants who develop food allergy display a proinflammatory immune profile in cord blood, but how this is related to interleukin-4 (IL-4)/T helper 2 (TH2)-type immunity characteristic of allergy is unknown. In a general population-derived birth cohort, we found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4+ T cell ratio and a lower proportion of natural regulatory T cell (nTreg) in relation to duration of labor. CD14+ monocytes of food-allergic infants secreted higher amounts of inflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor-α) in response to lipopolysaccharide. In the presenc..
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Funding Acknowledgements
This work was supported by grants from the Australian National Health and Medical Research Council (NHMRC) (1037321 to L.C.H., 1029927 and 1082307 to P.V., and 607370 to A.-L.P.), Juvenile Diabetes Research Foundation (17-2013-547 to L.C.H. and Y.Z.), and Walter and Eliza Hall Institute Catalyst Fund (45941 to Y.Z.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian NHMRC Research Institute Infrastructure Support Scheme. We thank the BIS participants for their contribution.