Journal article
Progression of atrial remodeling in patients with high-burden atrial fibrillation: Implications for early ablative intervention
TE Walters, A Nisbet, GM Morris, G Tan, M Mearns, E Teo, N Lewis, A Ng, P Gould, G Lee, S Joseph, JB Morton, D Zentner, P Sanders, PM Kistler, JM Kalman
Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2016
Abstract
Background Advanced atrial remodeling predicts poor clinical outcomes in human atrial fibrillation (AF). Objective The purpose of this study was to define the magnitude and predictors of change in left atrial (LA) structural remodeling over 12 months of AF. Methods Thirty-eight patients with paroxysmal AF managed medically (group 1), 20 undergoing AF ablation (group 2), and 25 control patients with no AF history (group 3) prospectively underwent echocardiographic assessment of strain variables of LA reservoir function at baseline and at 4, 8, and 12 months. In addition, P-wave duration (Pmax,, Pmean) and dispersion (Pdis) were measured. AF burden was quantified by implanted recorders. Twenty..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Melbourne Health Foundation (GIA MH2013-127). Dr. Walters is a recipient of a research scholarship from the National Health and Medical Research Council (NHMRC) of Australia and the National Heart Foundation of Australia. Professors Sanders, Kistler, and Kalman are supported by Practitioner Fellowships from the NHMRC. Address reprint requests and correspondence: Prof. Jonathan M. Kalman, Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia. E-mail address: jon.kalman@mh.org.au.