Reactions of β-trimethylstannylcyclohexanones with peracids: Investigations into the stannyl-directed Baeyer-Villiger reaction

Abstract

The trimethylstannyl subsituent raises the migratory aptitude of a primary β-carbon to be above that of a not otherwise activated secondary or tertiary carbon. This is apparent from the exclusive formation of the alkene acids 9-11 from Baeyer-Villiger reaction of the β-stannyl cyclohexanones 3-5. The stereoelectronic requirements of the stannyl-directed Baeyer-Villiger reaction were investigated using the axial β-trimethylstannlcyclohexanone 20.