Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes
AJM Verberne, WS Korim, A Sabetghadam, IJ Llewellyn-Smith
BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2016
Adrenaline is a hormone that has profound actions on the cardiovascular system and is also a mediator of the fight-or-flight response. Adrenaline is now increasingly recognized as an important metabolic hormone that helps mobilize energy stores in the form of glucose and free fatty acids in preparation for physical activity or for recovery from hypoglycaemia. Recovery from hypoglycaemia is termed counter-regulation and involves the suppression of endogenous insulin secretion, activation of glucagon secretion from pancreatic α-cells and activation of adrenaline secretion. Secretion of adrenaline is controlled by presympathetic neurons in the rostroventrolateral medulla, which are, in turn, un..View full abstract
Related Projects (3)
This work was supported by grants from the National Health and Medical Research Council of Australia to A.J.M.V and I.J.L-S, the Austin Medical Research Foundation to A.J.M.V., W.S.K. and A.S. and a University of Melbourne International Postgraduate student award to A.S.