Integrating Biomaterials and Stem Cells for Neural Regeneration
Francesca L Maclean, Alexandra L Rodriguez, Clare L Parish, Richard J Williams, David R Nisbet
STEM CELLS AND DEVELOPMENT | MARY ANN LIEBERT, INC | Published : 2016
The central nervous system has a limited capacity to regenerate, and thus, traumatic injuries or diseases often have devastating consequences. Therefore, there is a distinct need to develop alternative treatments that can achieve functional recovery without side effects currently observed with some pharmacological treatments. Combining biomaterials with pluripotent stem cells (PSCs), either embryonic or induced, has the potential to revolutionize the treatment of neurodegenerative diseases and traumatic injuries. Biomaterials can mimic the extracellular matrix and present a myriad of relevant biochemical cues through rational design or further functionalization. Biomaterials such as nanofibe..View full abstract
Awarded by NHMRC
F.L.M. and A.L.R. were supported by an Australian Postgraduate Award; C.L.P. was supported by an NHMRC Career Development Award, and subsequently Senior Medical Research Fellowship provided by the Viertel Charitable Foundation, Australia; R.J.W. was funded by an Alfred Deakin Research Fellowship; and D.R.N. was supported by an NHMRC Career Development Fellowship (APP1050684). Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged.