Phylogenomic and biogeographic reconstruction of the Trichinella complex

Pasi K Korhonen; Edoardo Pozio; Giuseppe La Rosa; Bill CH Chang; Anson V Koehler; Eric P Hoberg; Peter R Boag; Patrick Tan; Aaron R Jex; Andreas Hofmann; Paul W Sternberg; Neil D Young; Robin B Gasser

Journal article

Phylogenomic and biogeographic reconstruction of the Trichinella complex

Pasi K Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill CH Chang, Anson V Koehler, Eric P Hoberg, Peter R Boag, Patrick Tan, Aaron R Jex, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/ncomms10513

Download PDF

Abstract

Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and..

View full abstract

University of Melbourne Researchers

Bill Chang Author Veterinary Biosciences

Peter Boag Author Veterinary Biosciences

Anson Koehler Author Veterinary Biosciences

Robin Gasser Author Veterinary Biosciences

Pasi Korhonen Author Veterinary Biosciences

Related Projects (6)

Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions

Frontier technologies will be used in this project to unlock the molecular secrets of parasites which cause serious food-borne diseases in a..

CATCHMENT SOURCES OF MICROORGANISMS DEVELOPING AN INTEGRATED STRATEGY FOR THE SUSTAINED PREVENTION OF WATERBORNE DISEASE OUTBREAKS IN HUMANS IN MELBOURNE

Establishing next-generation technology platforms for the detection and monitoring of microorganisms in Melbourne Water catchments

This project will establish a major scientific and technological program in national priority areas to protect drinking water catchments. Th..

Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions

Frontier technologies will be used in this project to unlock the molecular secrets of parasites which cause serious food-borne diseases in a..

Discovering the function and structure of RIO kinases - toward new nematocides

This project is focused on: high quality fundamental molecular science, contributing to national objectives, including the development of no..

Establishing next-generation technology platforms for the detection and monitoring of microorganisms in Melbourne Water catchments

This project will establish a major scientific and technological program in national priority areas to protect drinking water catchments. Th..

Grants

Awarded by Victorian Life Sciences Computation Initiative

Funding Acknowledgements

Funding from the Australian Research Council, the National Health and Medical Research Council (NHMRC) of Australia, Yourgene Bioscience and Melbourne Water Corporation is gratefully acknowledged (R.B.G. et al.). This project was funded in part through DG SANCO of the European Commission and Istituto Superiore di Sanita, Rome (E.P.). This project was also supported by a Victorian Life Sciences Computation Initiative (grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (R.B.G.). N.D.Y. holds an NHMRC Early Career Research Fellowship. P.W.S. thanks the Howard Hughes Medical Institute (HHMI) and the National Institutes of Health (NIH). We thank the staff of Yourgene Bioscience for their contributions. We would specifically like to acknowledge all scientists who developed the programmes used in this study. Given restrictions on the number of articles that could be cited, we were unable to include all original articles in the Methods section. Instead, we have included links to respective websites. P.K.K. is the recipient of a scholarship (STRAPA) from the University of Melbourne.