Phylogenomic and biogeographic reconstruction of the Trichinella complex
Pasi K Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill CH Chang, Anson V Koehler, Eric P Hoberg, Peter R Boag, Patrick Tan, Aaron R Jex, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser
NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2016
Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and..View full abstract
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Awarded by Victorian Life Sciences Computation Initiative
Funding from the Australian Research Council, the National Health and Medical Research Council (NHMRC) of Australia, Yourgene Bioscience and Melbourne Water Corporation is gratefully acknowledged (R.B.G. et al.). This project was funded in part through DG SANCO of the European Commission and Istituto Superiore di Sanita, Rome (E.P.). This project was also supported by a Victorian Life Sciences Computation Initiative (grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (R.B.G.). N.D.Y. holds an NHMRC Early Career Research Fellowship. P.W.S. thanks the Howard Hughes Medical Institute (HHMI) and the National Institutes of Health (NIH). We thank the staff of Yourgene Bioscience for their contributions. We would specifically like to acknowledge all scientists who developed the programmes used in this study. Given restrictions on the number of articles that could be cited, we were unable to include all original articles in the Methods section. Instead, we have included links to respective websites. P.K.K. is the recipient of a scholarship (STRAPA) from the University of Melbourne.