Reconstruction of the insulin-like signalling pathway of Haemonchus contortus

Namitha Mohandas; Min Hu; Andreas J Stroehlein; Neil D Young; Paul W Sternberg; James B Lok; Robin B Gasser

Journal article

Reconstruction of the insulin-like signalling pathway of Haemonchus contortus

Namitha Mohandas, Min Hu, Andreas J Stroehlein, Neil D Young, Paul W Sternberg, James B Lok, Robin B Gasser

PARASITES & VECTORS | BMC | Published : 2016

DOI: 10.1186/s13071-016-1341-8

Download PDF

Abstract

BACKGROUND: In the present study, we reconstructed the insulin/insulin-like growth factor 1 signalling (IIS) pathway for Haemonchus contortus, which is one of the most important eukaryotic pathogens of livestock worldwide and is related to the free-living nematode Caenorhabditis elegans. METHODS: We curated full-length open-reading frames from assembled transcripts, defined the complement of genes that encode proteins involved in this pathway and then investigated the transcription profiles of these genes for all key developmental stages of H. contortus. RESULTS: The core components of the IIS pathway are similar to their respective homologs in C. elegans. However, there is considerable vari..

View full abstract

University of Melbourne Researchers

Namitha Mohandas Author Veterinary Biosciences

Robin Gasser Author Veterinary Biosciences

Neil Young Author Veterinary Biosciences

Related Projects (3)

GENOME-BASED TOOLS TO SUPPORT UROGENITAL SCHISTOSOMIASIS CONTROL

More than 100 million sub-Saharan Africans have urogenital schistosomiasis, a disease that promotes malignant cancer and HIV/AIDS. Control d..

New Drugs against Neglected Parasitic Worms

Discovering the function and structure of RIO kinases - toward new nematocides

This project is focused on: high quality fundamental molecular science, contributing to national objectives, including the development of no..

Grants

Awarded by Victorian Life Sciences Computation Initiative (VLSCI)

Awarded by National Key Basic Research Program (973 program) of China

Awarded by National Natural Science Foundation of China (NSFC)

Awarded by National Institute of Health (NIH), USA

Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

Funding from the Australian Research Council (ARC) and the National Health and Medical Research Council of Australia (NHMRC) is gratefully acknowledged, as is support from the Victorian Life Sciences Computation Initiative (VLSCI; grant number VR0007) (RBG). Other support was from grants from the National Key Basic Research Program (973 program) of China (no. 2015CB150300), the National Natural Science Foundation of China (NSFC) (no. 31172310) (MH) and from the National Institute of Health (NIH), USA (AI-50688) (JBL). We acknowledge the contributions of staff at WormBase (www.wormbase.org). AJS is a recipient of a Melbourne International Research Scholarship (MIRS) and a Melbourne International Fee Remission Scholarship (MIFRS) from The University of Melbourne.