Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

Fa-Cai Li; Robin B Gasser; James B Lok; Pasi K Korhonen; Li He; Wen-Da Di; Fang-Yuan Yin; Rui Zhou; Yan-Qin Zhou; Jun-Long Zhao; Min Hu

Journal article

Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

Fa-Cai Li, Robin B Gasser, James B Lok, Pasi K Korhonen, Li He, Wen-Da Di, Fang-Yuan Yin, Rui Zhou, Yan-Qin Zhou, Jun-Long Zhao, Min Hu

PARASITES & VECTORS | BMC | Published : 2016

DOI: 10.1186/s13071-016-1351-6

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Abstract

BACKGROUND: Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) and activates protein kinases of the AGC family, plays critical roles in regulating biology processes, such as metabolism, growth, development and survival. In the free-living nematode Caenorhabditis elegans, PDK-1 is a key component of the insulin-like signalling pathway, regulating the entry into and exit from dauer (arrested development). Although it is proposed that similar molecular mechanisms control the transition from the free-living to the parasitic stages of nematodes, nothing is known about PDK-1 in Haemonchus contortus, a socioeconomically important gas..

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University of Melbourne Researchers

Robin Gasser Author Veterinary Biosciences

Pasi Korhonen Author Veterinary Biosciences

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Grants

Awarded by National Natural Science Foundation of China (NSFC)

Awarded by National Key Basic Research Program (973 program) of China

Awarded by Special Fund for Agro-scientific Research in the Public Interest, China

Awarded by National Institute of Health (NIH), USA

Awarded by Victoria Life Sciences Computation Initiative (VLSCI)

Funding Acknowledgements

This study was supported by "National Natural Science Foundation of China (NSFC)" (Grant no. 31172310), the National Key Basic Research Program (973 program) of China (Grant No. 2015CB150300) and "Special Fund for Agro-scientific Research in the Public Interest, China" (Grant no. 201303037) to MH, by a grant from The National Institute of Health (NIH), USA (AI-50688) to JBL and by funds from the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) of Australia to RBG. This study was also supported by a Victoria Life Sciences Computation Initiative (VLSCI; grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia (RBG).