Book Chapter

Developmental hemostasis i

P Monagle

Pediatric Thrombotic Disorders | Published : 2014

Abstract

The hemostatic system is a complex interaction between the vasculature, cellular components and plasma proteins that interact to maintain hemostasis in the healthy body. Further, this complex interaction occurs across a variety of flow states, under variable pressure conditions. The hemostatic system on a wider scale also interplays with other physiological systems, including those that facilitate immune and inflammatory responses, angiogenesis and wound repair. There is currently no mechanism for assessing or testing the hemostatic system in its true physiological state. All laboratory tests isolate specific components of the system, and assess those components under artificial constructs t..

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University of Melbourne Researchers