Monoclonal antibody to ICAM-1 prolongs murine heterotopic corneal allograft survival

Abstract

Graft rejection requires an initial interaction between donor antigen presenting cells (APC) and recipient T cells; an interaction known to involve a variety of cell surface molecules. We have been investigating an interaction involving two of these molecules: lymphocyte function associated antigen-1 (LFA-1) on the T cell and its ligand, intercellular adhesion molecule-1 (ICAM-1) on the APC, in an effort to assess the effect its interruption would have on the ability of the recipient to reject an allograft. A monoclonal antibody (MAb) against ICAM-1 was given peritransplant to mice with heterotopically grafted corneas. Mice were killed at various time points and the grafts taken for histolog..