Journal article
Salmonella phage ST64B encodes a member of the SseK/NleB effector family
NF Brown, BK Coombes, JL Bishop, ME Wickham, MJ Lowden, O Gal-Mor, DL Goode, EC Boyle, KL Sanderson, BB Finlay
Plos One | Published : 2011
Open access
Abstract
Salmonella enterica is a species of bacteria that is a major cause of enteritis across the globe, while certain serovars cause typhoid, a more serious disease associated with a significant mortality rate. Type III secreted effectors are major contributors to the pathogenesis of Salmonella infections. Genes encoding effectors are acquired via horizontal gene transfer, and a subset are encoded within active phage lysogens. Because the acquisition of effectors is in flux, the complement of effectors possessed by various Salmonella strains frequently differs. By comparing the genome sequences of S. enterica serovar Typhimurium strain SL1344 with LT2, we identified a gene with significant similar..
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Funding Acknowledgements
NFB, BKC, MEW and OG-M were supported by the Michael Smith Foundation for Health Research. BKC and MEW were also supported by Canadian Institutes of Health Research (CIHR) postdoctoral fellowships and NFB is supported by a National Health and Medical Research Council (NHMRC) Howard Florey Centenary fellowship. Research in NFB's laboratory is supported by a grant from NHMRC and research in BBF's laboratory is supported by grants from CIHR and the Howard Hughes Medical Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.