Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps
Nicholas G Burgess, Maria Pellise, Kavinderjit S Nanda, Luke F Hourigan, Simon A Zanati, Gregor J Brown, Rajvinder Singh, Stephen J Williams, Spiro C Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Heok P'Ng, Duncan McLeod, Michael J Bourke
GUT | BMJ PUBLISHING GROUP | Published : 2016
OBJECTIVE: The serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia (SSA/P-D) are a high-risk serrated CRC precursor with little existing data. We aimed to describe the clinical and endoscopic predictors of SSA/P-D and high grade dysplasia (HGD) or cancer. DESIGN: Prospective multicentre data of SSA/Ps ≥20 mm referred for treatment by endoscopic mucosal resection (September 2008-July 2013) were analysed. Imaging and lesion assessment was standardised. Histological findings were correlated with clinical and endoscopic findings. RESULTS: 268 SSA/Ps were found in 207/1546 patients (13.4%..View full abstract
NGB was supported by a funding grant from the Westmead Medical Research Foundation (WMRF). The Cancer Institute New South Wales provided funding for a research nurse and data manager to assist with the administration of the study. There was no influence from the WMRF or the Cancer Institute on study design or conduct, data collection and management, analysis, interpretation, preparation and review or approval of the manuscript.