Journal article

RNA EDITING RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Brian J Liddicoat, Robert Piskol, Alistair M Chalk, Gokul Ramaswami, Miyoko Higuchi, Jochen C Hartner, Jin Billy Li, Peter H Seeburg, Carl R Walkley

Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2015


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by Stanford Genome Training Program (NIH)

Awarded by NIH

Funding Acknowledgements

We thank V. Sankaran, S. Orkin, L. Purton, and J. Heierhorst for discussion and SVH BioResources Centre for animal care. Data sets described in the paper are deposited in Gene Expression Omnibus (accession number GSE58917). This work was supported by the Leukaemia Foundation (C.R.W.), a Leukaemia Foundation Ph.D. scholarship (B.J.L), National Health and Medical Research Council (NHMRC) Project Grant 1021216, NHMRC Career Development Award 559016 (C.R.W.), a German Academic Exchange Service Postdoctoral Fellowship (R.P.), a Stanford University Dean's Fellowship (R.P.), Stanford Genome Training Program (NIH grant T32 HG000044) and Stanford Graduate Fellowship (G.R.), NIH grant R01GM102484 (J.B.L.), the Ellison Medical Foundation (J.B.L.), and the Stanford University Department of Genetics (J.B.L.). This work was also supported in part by the Victorian State Government Operational Infrastructure Support Scheme (to St. Vincent's Institute of Medical Research). C. R.W. was the Leukaemia Foundation Phillip Desbrow Senior Research Fellow. J.C.H. is an employee of Taconic Biosciences. Taconic Biosciences had no role in the preparation and content of this Report. All other authors declare no conflicts of interest. Author contributions: M.H., P.H.S., and J.C.H. generated the knock-in mouse line; B.J.L., R.P., A.M.C., G.R., J.C.H., J.B.L., and C.R.W. performed experiments and analyzed and interpreted data; M.H., P.H.S., and J.C.H. provided intellectual input and conceptual advice; and B.J.L. and C.R.W. wrote the manuscript.