Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk A Meta-analytical Stratification
Paolo Fusar-Poli, Marco Cappucciati, Stefan Borgwardt, Scott W Woods, Jean Addington, Barnaby Nelson, Dorien H Nieman, Daniel R Stahl, Grazia Rutigliano, Anita Riecher-Roessler, Andor E Simon, Masafumi Mizuno, Tae Young Lee, Jun Soo Kwon, May ML Lam, Jesus Perez, Szabolcs Keri, Paul Amminger, Sibylle Metzler, Wolfram Kawohl Show all
JAMA PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2016
IMPORTANCE: Individuals can be classified as being at clinical high risk (CHR) for psychosis if they meet at least one of the ultra-high-risk (UHR) inclusion criteria (brief limited intermittent psychotic symptoms [BLIPS] and/or attenuated psychotic symptoms [APS] and/or genetic risk and deterioration syndrome [GRD]) and/or basic symptoms [BS]. The meta-analytical risk of psychosis of these different subgroups is still unknown. OBJECTIVE: To compare the risk of psychosis in CHR individuals who met at least one of the major inclusion criteria and in individuals not at CHR for psychosis (CHR-). DATA SOURCES: Electronic databases (Web of Science, MEDLINE, Scopus) were searched until June 18, 20..View full abstract
Awarded by European Community
This study was supported in part by a 2014 NARSAD Young Investigator Award (Dr Fusar-Poli). The research leading to these results has also received funding from the European Community's Seventh Framework Programme under grant agreement HEALTH-F2-2013-603196 (Project PSYSCAN [Translating Neuroimaging Findings from Research into Clinical Practice]).