Journal article

The trajectory of cognitive functioning following first episode mania: A 12-month follow-up study

Rothanthi Daglas, Kelly Allott, Murat Yucel, Christos Pantelis, Craig A Macneil, Michael Berk, Sue M Cotton

Australian & New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2016

Abstract

OBJECTIVES: Cognitive deficits are apparent in the early stages of bipolar disorder; however, the timing and trajectory of cognitive functioning following a first episode of mania remains unclear. The aim of this study was to assess the trajectory of cognitive functioning in people following a first episode of mania over a 12-month period, relative to healthy controls. METHOD: The cohort included 61 participants who had recently stabilised from a first treated manic episode, and 21 demographically similar healthy controls. These groups were compared on changes observed over time using an extensive cognitive battery, over a 12-month follow-up period. RESULTS: A significant group by time inter..

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Grants

Awarded by AstraZeneca


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study involved secondary analyses from a RCT that was supported by an investigator-initiated grant from AstraZeneca (D1443C00002). This funding source had no influence on the study design and was not involved in data collection, data analysis and interpretation of the results.