The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration

PS Sachdev; DM Lipnicki; NA Kochan; JD Crawford; A Thalamuthu; G Andrews; C Brayne; FE Matthews; BCM Stephan; RB Lipton; MJ Katz; K Ritchie; I Carrière; ML Ancelin; LCW Lam; CHY Wong; AWT Fung; A Guaita; R Vaccaro; A Davin; M Ganguli; H Dodge; T Hughes; KJ Anstey; N Cherbuin; P Butterworth; TP Ng; Q Gao; S Reppermund; H Brodaty; N Schupf; J Manly; Y Stern; A Lobo; R Lopez-Anton; J Santabárbara; M Zimmerman; C Derby; GTY Leung; WC Chan; L Polito; S Abbondanza; E Valle; M Colombo; SF Vitali; S Fossi; D Zaccaria; G Forloni; S Villani; H Christensen; A MacKinnon; S Easteal; T Jacomb; K Maxwell; A Bowman; K Burns; A Broe; J Dekker; L Dooley; M De Permentier; S Fairjones; J Fletcher; T French; C Foster; E Nugent-Cleary-Fox; C Gooi; E Harvey; R Helyer; S Hsieh; L Hughes; S Jacek; M Johnston; D McCade; S Meeth; E Milne; A Moir; R O'Grady; K Pfaeffli; C Pose; L Reuser; A Rose; P Schofield; Z Shahnawaz; A Sharpley; C Thompson; W Queisser; S Wong; R Mayeux; A Brickman; J Luchsinger; D Sanchez; MX Tang; H Andrews; G Marcos; C De-La-Cámara; P Saz; T Ventura; MA Quintanilla; E Lobo

Journal article

The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration

PS Sachdev, DM Lipnicki, NA Kochan, JD Crawford, A Thalamuthu, G Andrews, C Brayne, FE Matthews, BCM Stephan, RB Lipton, MJ Katz, K Ritchie, I Carrière, ML Ancelin, LCW Lam, CHY Wong, AWT Fung, A Guaita, R Vaccaro, A Davin Show all

Plos One | Published : 2015

DOI: 10.1371/journal.pone.0142388

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Abstract

Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first defin..

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University of Melbourne Researchers

Andrew MacKinnon Author

Grants

Awarded by Novartis

Funding Acknowledgements

National Health and Medical Research Council of Australia Program Grant (ID 568969; PSS). For the contributing studies: Major awards from the UK Medical Research Council and the Department of Health (CB, FEM, BCMS); National Institute on Health/National Institute on Aging grants (5P01 AG003949, 1R03 AG045474; RBL, MJK); Novartis (KR, MLA, IC); Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and an educational fund from Eisai (LCWL, CHYW, AWTF); Fondazione Golgi Cenci and Federazione Alzheimer Italia (AG, RV, AD); National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services (Grant # R01AG07562; MG, HD, TH); National Health and Medical Research Council of Australia (Grants 973302, 179805, 157125 and 1002160; KJA, NC, PB); Research grants (No. 03/121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore (TPN, QG); National Health & Medical Research Council of Australia Program Grant (ID 350833; PSS, DML, NAK, JDC, AT, GA, SR, HB); National Institute of Health/National Institute on Aging (Grants # R01 AG037212, P01 AG07232; NS, JM, YS); Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (Grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid (AL, RLA, JS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.