Journal article
Clinical and pathologic features of familial pancreatic cancer
JL Humphris, AL Johns, SH Simpson, MJ Cowley, M Pajic, DK Chang, AM Nagrial, VT Chin, LA Chantrill, M Pinese, RS Mead, AJ Gill, JS Samra, JG Kench, EA Musgrove, KM Tucker, AD Spigelman, N Waddell, SM Grimmond, AV Biankin
Cancer | Published : 2014
DOI: 10.1002/cncr.28863
Abstract
METHODS: Clinicopathologic features were assessed in a cohort of 766 patients who had been diagnosed with pancreatic ductal adenocarcinoma (PC). Patients were classified with FPC if they had ≥1 affected first-degree relatives; otherwise, they were classified with sporadic PC (SPC).BACKGROUND: Inherited predisposition to pancreatic cancer contributes significantly to its incidence and presents an opportunity for the development of early detection strategies. The genetic basis of predisposition remains unexplained in a high proportion of patients with familial PC (FPC).RESULTS: The prevalence of FPC in this cohort was 8.9%. In FPC families with an affected parent-child pair, 71% in the subsequ..
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Awarded by Cancer Research UK
Funding Acknowledgements
This work was supported by the Avner Nahmani Pancreatic Cancer Foundation; the Gastroenterological Society of Australia; the National Health and Medical Research Council of Australia; the Australian Government Department of Innovation, Industry, Science and Research; the Australian Cancer Research Foundation; the Queensland Government; the University of Queensland; Cancer Council NSW; Cancer Institute NSW; the Philip Hemstritch Foundation; the Royal Australasian College of Surgeons; the Royal Australasian College of Physicians; and the Royal College of Pathologists of Australasia.