Journal article

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Jing Yu, M Todd Valerius, Mary Duah, Karl Staser, Jennifer K Hansard, Jin-jin Guo, Jill McMahon, Joe Vaughan, Diane Faria, Kylie Georgas, Bree Rumballe, Qun Ren, A Michaela Krautzberger, Jan P Junker, Rathi D Thiagarajan, Philip Machanick, Paul A Gray, Alexander van Oudenaarden, David H Rowitch, Charles D Stiles Show all

DEVELOPMENT | COMPANY OF BIOLOGISTS LTD | Published : 2012

Abstract

Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers an..

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Grants

Awarded by National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

M.H.L. is a Principal Research Fellow of the National Health and Medical Research Council. The work was supported by a National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant [5U01 DK070181 to A.P.M. and DK070136 to M.H.L.]. T.L.B. and P.M. were supported by an NIH R01 grant [RR021692]. Q.R. and J.Y. were supported by a NIH/NIDDK grant [1R01DK085080]. Deposited in PMC for release after 12 months.