Journal article
Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrin
Y Cao, LH Hoeppner, S Bach, E Guangqi, Y Guo, E Wang, J Wu, MJ Cowley, DK Chang, N Waddell, SM Grimmond, AV Biankin, RJ Daly, X Zhang, D Mukhopadhyay
Cancer Research | Published : 2013
Abstract
Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding the extravasation process or re-entry of circulating tumor cells at metastatic sites. Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF), and other growth factors, expressed on cancer cells interacts with α5 integrin on endothelial cells to mediate vascular extravasation and metastasis in zebrafish and murine xenograft models of clear cell renal cell carcinoma ..
View full abstractGrants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was partly supported by CA78383 and CA150190, and the Bruce and Martha Atwater Foundation (D. Mukhopadhyay) and grant No. 31101016 (Y. Cao) from the National Natural Science Foundation of China. D. Mukhopadhyay is a visiting professor at King Saud University (Riyadh, Saudi Arabia). L.H. Hoeppner is a fellow of NCI-T32 CA148073 and 13POST14510025 from the American Heart Association.