Journal article
Profiling gene expression induced by protease activated receptor 2 (PAR2) activation in human kidney cells
JY Suen, B Gardiner, S Grimmond, DP Fairlie
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Protease-Activated Receptor-2 (PAR2) has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD) and key events in tumor progression (angiogenesis, metastasis), but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293), a commonly studied ce..
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Awarded by Australian Research Council
Funding Acknowledgements
Research funding is from the National Health and Medical Research Council of Australia (NHMRC569595; www.nhmrc.gov.au) and the Australian Research Council for a Federation Fellowship to DPF (FF0668733; www.arc.gov.au). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.